Tuning Repolarization in the Heart
نویسندگان
چکیده
منابع مشابه
Tuning repolarization in the heart: a multitude of potassium channels and regulatory pathways.
Approximately one decade after the cloning of the first potassium channel, potassium channel genes of amazing diversity have emerged, many of them expressed in the heart. A magnitude of a subunits forming homotetramers or heterotetramers, multiple regulatory subunits, and alternative splicing of genes adds up to a seemingly endless diversity of potassium channels. Considering the relative unifo...
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Background Anthracyclines are important components of many chemotherapeutic protocols. The present study aimed to evaluate the repolarization changes in electrocardiography (ECG) which may predict drug induced arrhythmia. Materials and Methods In this cross-sectional study, the recorded ECGs were assessed for QT dispersion (QTd), QT corrected dispersion (QTcd), T peak to Tend dispersion (TPe...
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The effect of current flow on the transmembrane action potential of single fibers of ventricular muscle has been examined. Pulses of repolarizing current applied during the plateau of the action potential displace membrane potential much more than do pulses of depolarizing current. The application of sufficiently strong pulses of repolarizing current initiates sustained repolarization which per...
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In 1880, Burdon-Sanderson and Page recorded the ECG of the frog simultaneously with monophasic action potentials from the base and the apex of the left ventricle (LV).1 Part of the ventricular muscle was injured with a hot wire, and monophasic action potentials were recorded as the potential difference between the injured region and an uninjured area. The ECG was recorded with a capillary elect...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2001
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.88.5.453